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KMID : 1094720160210020199
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Biotechnology and Bioprocess Engineering
2016 Volume.21 No. 2 p.199 ~ p.223
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Recent progress on the development of antibiotics from the genus Micromonospora
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Boumehira Ali Zineddine
El-Enshasy Hesham Ali
Hacene Hocine
Elsayed Elsayed Ahmed
Aziz Ramlan
Park Enoch Y.
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Abstract
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The emergence of a large number of antimicrobialresistant organisms is a cause for concern. Nature is historically the source of drugs; indeed a considerable number of drugs have been developed from microorganisms, and are now used daily in the treatment of infectious diseases. However, the introduction to the pharmaceutical market of new therapeutic molecules has decreased during the last two decades. In this review, the genus Micromonospora is proposed as a biofactory for production of new antibiotics. The genus Micromonospora has been investigated extensively and more than 100 antibiotics have been isolated from diverse Micromonospora strains. In addition, recent developments in analytical, biological and bioinformatics screening tools used in the discovery of new therapeutic compounds are described. It may be possible to revive formerly used antibiotics produced by Micromonospora and study of this genus may facilitate discovery of novel bioactive molecules.
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KEYWORD
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Micromonospora, antibiotics, drug discovery, gentamicin, secondary metabolites, natural products
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